SAN DIEGO -- Peyton Manning was sick and sore.
He took four bags of intravenous fluid between Saturday night and Sunday morning, and then hurt his right thigh in the second quarter, requiring more treatment.
It was all good, though. Nothing a victory and a fourth straight AFC West title won't cure.
Manning threw a 28-yard touchdown pass to Demaryius Thomas in the third quarter and Connor Barth kicked five field goals to lead Denver to a 22-10 victory against the San Diego Chargers on Sunday that clinched the division title.
"He was sick. I don't think it was Jordan game flu sick, but he was sick," running back C.J. Anderson said, referring to how sick Michael Jordan was when he scored 38 points in Game 5 of the 1997 NBA Finals.
"He went out there and battled," Anderson added. "He battled the Chargers' D, battled the crowd, battled the adversity and battled himself. That's a lot of battles going on in one man's lifetime right now. But he went out there and overcame it and helped us out with a 'W' today."
Manning said he first started feeling ill Saturday evening.
"I had a rough night. I'm not going to lie, it wasn't an enjoyable night," Manning said. "It came out of nowhere."
Manning came out of the game late in the second quarter. He said he was hurt while scrambling to his right and completing a pass to Emmanuel Sanders. Three plays later, he blocked linebacker Donald Butler on a run by Anderson.
The Broncos had to settle for a field goal and Manning headed to the locker room while Brock Osweiler led an unproductive series.
"I was in some discomfort and had some limitations," Manning said. "If you can't do your job, you can't move, if you hurt yourself, you hurt the team."
Manning was one of the last Broncos out of the locker room for the start of the second half, cheered on by the thousands of Broncos fans at Qualcomm Stadium.
"We were unsure at halftime to be honest with you, until Peyton made the cavalry entrance there at the start of the third quarter," coach John Fox said. "I think it's a tribute to the kind of toughness Peyton has and the kind of competitor he is that he got up and did a tremendous job in those conditions."
Osweiler was warming up "and all of a sudden I heard this loud cheer and I didn't even need to turn around. I knew exactly what it was."
Manning was back in time for Denver's first possession of the third quarter. He capped the second possession with a 28-yard touchdown pass to Thomas to give the Broncos a 16-3 lead.
The Broncos (11-3) won their fourth straight game and are tied with New England for the AFC's best record. New England beat the Broncos 43-21 on Nov. 2.
Denver's 12th straight division road win tied San Francisco's NFL record set from 1987-90.
The Chargers (8-6) entered the game as the AFC's No. 6 seed and saw their wild-card chances diminished. They lost a week earlier to New England.
"It's just a two-game streak against the two top teams in the conference," said Philip Rivers, who threw one touchdown pass and was intercepted twice. "We're not in their company yet. It's not like we've lost to the bottom of the barrel."
Manning completed 14 of 20 passes for 233 yards with one touchdown and no interceptions. He extended his own NFL record to 14 seasons with 4,000 yards passing.
A week earlier, Manning's touchdown streak came to a halt at 51 games, three shy of Drew Brees' NFL record, and he was picked off twice for the fourth time in the past six games.
San Diego pulled within six points when Antonio Gates caught a 5-yard pass from Rivers with 10:13 left. Gates joined Rob Gronkowski as the only tight ends in NFL history with four seasons with at least 10 touchdown catches.
Then Manning led the Broncos on a drive capped by Barth's 49-yard field goal with 4:53 to play. After Aqib Talib intercepted Rivers, Barth kicked a 44-yarder to give the Broncos a 12-point lead.
The Broncos got inside the Chargers 10 on consecutive drives in the first half but had to settle for field goals each time.
Thomas had six catches for 123 yards and Anderson ran 29 times for 85 yards. ... Broncos left tackle Ryan Clady (thigh) and linebacker Brandon Marshall (foot) left the game and didn't return. ... Butler was spun around by Manning's block and ended up on the ground. He left with an elbow injury. ... Chargers wide receiver Keenan Allen left with an ankle injury.
Jets cornerback Antonio Cromartie added fuel to the New York rivalry when he explained why he thinks Giants star wideout Odell Beckham Jr. is a "one-year wonder."
Brian Hoyer is the Houston Texans' starting quarterback for the team's Week 6 game against the Jaguars. For how long he remains beyond that game is uncertain.
The Seattle Seahawks have ruled running back Marshawn Lynch out for Sunday's game against the Cincinnati Bengals due to a hamstring injury.
New Orleans Saints first-round draft pick Andrus Peat will make his starting debut at left tackle against the Eagles in place of injured Terron Armstead.
Stephen Gostkowski of the New England Patriots is the best kicker in the NFL, according to an NFL Nation survey of his peers.
Detroit Lions vice chairman Bill Ford Jr. said Friday on WJR Radio that his mother, owner Martha Ford, is in full control of the franchise.