The Astros were swept by the A's in a three-game series in Oakland last week, and there seemed to still be some animosity between the teams from an 11-3 loss in the first game of that series.
In that game, Clemens appeared to try to hit Lowrie with a pitch in the third inning after Lowrie had attempted a bunt in the first with Oakland up by seven runs. Houston manager Bo Porter came out of the dugout to scream at Lowrie after he hit a fly out following two inside pitches.
On Thursday night, Clemens was tossed after hitting Lowrie on the backside with the first pitch of the at-bat with Oakland leading 8-1. Lowrie had doubled off him in the fifth.
"It's flat-out embarrassing," Lowrie said of the incident. "There's no other way to say it. Every perspective, every angle you look at it, it's embarrassing. That kind of conduct shouldn't be condoned."
The Astros denied Lowrie was hit intentionally.
"There was no carry-over on my end," Clemens said. "What happened in Oakland was squashed in Oakland. Bad pitch there. It just so happened I cut a fastball. We wanted to go inside on him."
Lowrie got a bit of justice when Josh Donaldson hit his second home run after the plunking.
"I love it. I love it," Lowrie repeated when asked about the homer.
Porter was evasive when asked whether Clemens hit Lowrie on purpose.
"I think the game of baseball takes care of itself," he said. "George Springer got hit tonight, and it's part of the game."
Lowrie said he has never seen anything like this and that he holds Porter responsible for what happened.
"At the end of the day, the buck stops with him, so if you look at it that way, yes, he's the one that's responsible for players' conduct," he said.
Donaldson hit a pair of two-run homers to help the Athletics cruise to the victory.
It was the first career multihomer game for Donaldson, who connected in the first inning and pushed the lead to 10-1 with a second shot in the seventh. Alberto Callaspo added a two-run homer in the third, and Lowrie had three hits for the A's, who improved to 24-5 against Houston, which joined the American League before the start of last season.
Scott Kazmir is off to a 3-0 start for the first time in his career after allowing five hits and a run with seven strikeouts in six innings. He lowered his ERA to 1.62.
The Athletics jumped on Houston starter Brett Oberholtzer (0-4) early and tagged him for a career-high six runs on eight hits, which tied a career high, in just 3 2/3 innings.
Houston's only run came on a bases-loaded walk in the first inning, and the Astros had trouble stringing any hits together. They had a terrible night on defense, committing five errors after entering the night leading the majors with a .992 fielding percentage and just seven errors.
Donaldson's towering 389-foot homer, which clanged high off the foul pole in left field, gave Oakland a 2-0 lead in the first inning. Houston cut it to 2-1 when Chris Carter drew a bases-loaded walk in the bottom of the inning.
The trouble continued for Oberholtzer in the second inning when Craig Gentry doubled with one out. He then plunked Brandon Moss before a two-out RBI bloop single by Coco Crisp. Crisp advanced to second on an error by Springer on the play.
Donaldson hit a leadoff double in the third and scored on a single by Derek Norris with one out to make it 4-1. Callaspo followed with his two-run home run to the Crawford Boxes in left field to push the lead to 6-1.
Gentry ended up on second base after a fielding error and a throwing error by Matt Dominguez on the same play.
Moss added an RBI single in the fifth inning, and Lowrie had a run-scoring double later in the inning to push the lead to 8-1.
A's left fielder Yoenis Cespedes left the game in the seventh inning with a strained left hamstring, and manager Bob Melvin said he expects him to be out a couple of days. ... Athletics RHP Jesse Chavez opposes RHP Brad Peacock in the second game of the series Friday night. ... Oakland RHP A.J. Griffin, sidelined since the start of the season with an elbow injury, will visit Dr. Thomas Mehlhoff in Houston on Tuesday for a second opinion. ... Houston reliever Matt Albers wasn't available for a third straight game Thursday because of tightness in his right shoulder. Porter said he doesn't think the problem is serious.