Here is a look at some things to know as you bet the Week 10 NFL games.
All lines are courtesy of Westgate Las Vegas SuperBook, and all games are on Sunday unless otherwise specified.
Case Keenum is 0-3 ATS with three outright losses in his career as a road favorite.
The Redskins are 7-3 ATS with seven outright wins in their past 10 games as a home underdog.
The Bears are favored against the Packers for the first time since December 22, 2008. In that game, Chicago won 20-17 in overtime as 4-point favorites. Green Bay had been favored in 18 straight meetings prior to this week.
This marks the sixth time in 41 games under John Fox that the Bears are a favorite. Chicago has lost outright in each of its previous five games when favored under Fox.
The Colts are 12-3 ATS with 10 outright wins in their past 15 games as a home underdog.
The under is 21-5 in the Steelers' past 26 road games.
The Jaguars are favored in their fourth straight game. This marks the first time Jacksonville will play four straight games as a favorite since Weeks 9-12 in 2006.
The Chargers are 6-0 ATS and 6-0 SU in their six meetings with the Jaguars since 2010.
The over is 14-2 in Ryan Fitzpatrick's past 16 starts as a home underdog.
The Buccaneers have the worst ATS record in the NFL this season at 1-6-1. Tampa Bay hasn't covered since its season opener in Week 2 against the Bears.
The over is 14-5 in Marcus Mariota's past 19 starts.
The over is 11-1 in the Bills' home games over the past two seasons.
The Bills are 7-0-1 ATS in their past eight games against NFC opponents.
The under is 7-0 in the Lions' past seven games against teams with a losing record.
Tom Savage is 0-4 ATS in four career NFL starts.
This will mark the first time that the Cowboys are an underdog this season. In Dak Prescott's first NFL season in 2016, Dallas went 4-1-1 ATS with four outright wins as a 'dog, with the only ATS loss coming in Week 17 at Philadelphia when the team was resting starters.
The over is 11-2 in the Falcons' past 13 home games.
The Giants have lost outright in each of their past three games as a favorite.
The Broncos are 5-1 ATS with five outright wins as a home underdog over the past three seasons. This includes a 3-1 ATS mark with three outright wins as a home 'dog to the Patriots during this span.
The total has gone under in four straight Patriots games after having gone over in eight straight prior to this stretch.
Jay Cutler has won outright in each of his past three games as an underdog of at least nine points. This includes a 20-17 win at Atlanta as a 13.5-point underdog in Week 6.